Undergraduate Institution: Eindhoven University of Technology
Graduate Institution: Eindhoven University of Technology
Phone: +31 40 247 5414
Office: CE 1.44
During my bachelor’s programme I developed a strong interest in the ability of arctic organisms to inhibit ice crystallization and growth in their blood serum. My bachelor’s thesis was therefore focused on studying the thermal hysteresis of type III antifreeze proteins. While remaining in the domain of bioinspired systems, I completed my master’s thesis aimed at understanding the interaction between the Uricase protein and crystalline monosodium urate monohydrate (MSU) which plays an essential role in the disease of gouty arthritis. Following my master’s thesis, I completed an internship at Philips Lighting where I studied the biochemical effects of sunlight on the human body at the Human Centric Lighting department. This research project focused on the identification of the essential technical parameters, responsible for beneficial biological health effects, and on the subsequent translation of this knowledge into the design of a viable product and business model. My continuing fascination with research on bioinspired systems led me to start a PhD project that follows up on the topic of my master’s thesis, under the supervision of Prof. Ilja Voets at the Institute of Complex Molecular Systems (ICMS).
My PhD project centers on understanding the binding interaction between MSU crystals and Uricase. In moving towards that goal, I use fluorescent protein labeling to study the changing properties of in vitro grown crystals upon addition of Uricase. Gaining more insights into the specific nature of this interaction could contribute to a better understanding of the mechanism of action of the Uricase and MSUs found in the body of patients suffering of gouty arthritis.