Undergraduate Institution: Mount Allison University, Sackville, Canada
Graduate Institution: Queen's University, Kingston, Canada
Phone: +31 40 247 5414
Office: CE 1.44
After completing high school in China, I moved to Canada to study Biochemistry (Major) and Chemistry (minor) for my bachelor degree at Mount Allison University. Following that I performed my PhD research under the guidance of Prof. Peter Davies At Queen’s University in Canada. My research focused on determining the structure of a giant 1.5-MDa protein that facilitates the bacterial biofilm formation.
My postdoctoral research in the Voets' group involves the use of protein engineering and synthetic biology approaches to study ice-nucleation/ antifreeze proteins/materials. In addition, I am also conducting research related to bacterial adhesins which are required for the formation of bacterial biofilms. Biofilms cause over 80% of the chronic bacterial infections. I am using a structure-guided approach to rationally design small molecules to block biofilms formed by these pathogens.
- Re-evaluation of a bacterial antifreeze protein as an adhesin with ice-binding activity. S. Guo, C.P. Garnham, J.C. Whitney, L.A. Graham, P.L. Davies. 2012. PloS One 7 (11)
- Structure of a 1.5-MDa adhesin that binds its Antarctic bacterium to diatoms and ice. S. Guo, C.A. Stevens, T.D.R. Vance, L.L.C. Olijve, L.A. Graham, R.L. Campbell, S. R. Yazdi, C. Escobedo, M. Bar-Dolev, V. Yashunsky, I. Braslavsky, D.N. Langelaan, S.P. Smith, J.S. Allingham, I.K. Voets, P.L. Davies. 2017. Science advances 3 (8), e1701440