Tim Hogervorst

Postdoc/guest

Nationality: Dutch
Undergraduate Institution: Leiden University
Graduate Institution: Leiden University
Email: t.p.hogervorst@tue.nl/t.p.hogervorst@uu.nl
Phone: +31 40 247 5414
Office: CE 1.44

Sub-group(s):

Biography:

After completing my bachelor’s degree in molecular science and technology, I started the master Chemistry at Leiden University. During my masters I worked on carbohydrate synthesis in the group of Prof. dr. Gijs van der Marel and Prof. dr. Jeroen D.C. Codée (Bio-organic synthesis group). After my masters I continued my PhD in the same group working on the synthesis of glycosylated conjugates as model vaccines. These conjugates were used to gain more understanding in the effect of the carbohydrate on the processing and presentation of antigens. Since February 2021 I exploit my carbohydrate and peptide synthesis skills for the synthesis of anti-freeze glycoproteins as a postdoc in the groups of dr. Tom Wennekes (Utrecht University) and Prof. dr. Ilja Voets.

 

Research interests:

I am working on the development of synthetic strategies to generate anti-freeze glycoproteins and study their interaction with ice surfaces.

Selected Publications:

Riera, R.*, Hogervorst, T. P.*, Doelman, W., Ni, Y., Pujals, S., Bolli, E., Codée, J. D. C., van Kasteren, S. I., & Albertazzi, L. (2021). Single-molecule imaging of glycan–lectin interactions on cells with Glyco-PAINT. Nature Chemical Biology, 17(12), 1281–1288. https://doi.org/10.1038/s41589-021-00896-2

Surís-Valls, R., Hogervorst, T. P., Schoenmakers, S. M. C., Hendrix, M. M. R. M., Milroy, L., & Voets, I. K. (2022). Inhibition of Ice Recrystallization by Nanotube-Forming Cyclic Peptides. Biomacromolecules, 23(2), 520–529. https://doi.org/10.1021/acs.biomac.1c01267

Li, R.-J. E.*, Hogervorst, T. P.*, Achilli, S., Bruijns, S. C., Arnoldus, T., Vivès, C., Wong, C. C., Thépaut, M., Meeuwenoord, N. J., van den Elst, H., Overkleeft, H. S., van der Marel, G. A., Filippov, D. V., van Vliet, S. J., Fieschi, F., Codée, J. D. C., & van Kooyk, Y. (2019). Systematic Dual Targeting of Dendritic Cell C-Type Lectin Receptor DC-SIGN and TLR7 Using a Trifunctional Mannosylated Antigen. Frontiers in Chemistry, 7(October), 1–15. https://doi.org/10.3389/fchem.2019.00650

Hogervorst, T. P.*, Li, R. J. E.*, Marino, L., Bruijns, S. C. M., Meeuwenoord, N. J., Filippov, D. V., Overkleeft, H. S., van der Marel, G. A., van Vliet, S. J., van Kooyk, Y., & Codée, J. D. C. (2020). C -Mannosyl Lysine for Solid Phase Assembly of Mannosylated Peptide Conjugate Cancer Vaccines. ACS Chemical Biology, 15(3), 728–739. https://doi.org/10.1021/acschembio.9b00987